Welcome on INSERM U999 website

Hypertension artérielle pulmonaire : physiopathologie et innovation thérapeutique

Director : Professor Marc HUMBERT

Team 1 :                                                                                Team 2 :

Program

Pulmonary hypertension describes a group of devastating diseases, comprising idiopathic and associated forms, causing breathlessness, loss of exercise capacity and death due to elevated pulmonary artery pressure and subsequent right heart failure. Pulmonary arterial hypertension is defined by an elevation of the mean pulmonary artery pressure above 25mmHg at rest and/or 30mmHg during exercise without elevation of the pulmonary capillary wedge pressure. Extensive pulmonary artery remodeling with loss of vessel patency is the underlying pathomechanism. The main scope of the Research Team "PULMONARY HYPERTENSION PATHOPHYSIOLOGY AND INNOVATIVE THERAPIES" relates to pulmonary hypertension pathophysiology and clinical management. Deciphering of the mechanisms of lung vascular remodeling and identification of novel molecular targets to alleviate and ultimately cure pulmonary hypertension is the main objective of this proposal. On the basis of a nationwide web-based Registry, a biobank, and highly competitive scientists, our group will study a number of molecular pathways causing pulmonary vascular remodeling in human and animal models of pulmonary hypertension, identify targets for therapy, foster drug development based on these targets and test novel treatments. Our main goal is to alleviate and cure pulmonary hypertension, a large burden to mankind, and to develop novel therapies.